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Related Experiment Videos

Leukopenia with cimetidine

S K Iyer, K L Chandrasekhara

    Journal of the National Medical Association
    |August 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    A patient developed leukopenia, a low white blood cell count, during cimetidine treatment for gastrointestinal bleeding. Symptoms resolved after discontinuing the medication, suggesting a link between cimetidine and leukopenia.

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    Area of Science:

    • Gastroenterology
    • Hematology
    • Pharmacology

    Background:

    • Sarcoid cirrhosis with portal hypertension is a complex condition.
    • Upper gastrointestinal bleeding due to gastritis requires effective management.

    Observation:

    • A patient with sarcoid cirrhosis and portal hypertension presented with upper gastrointestinal bleeding.
    • Cimetidine therapy was initiated to manage the bleeding episode.

    Findings:

    • Leukopenia, characterized by a reduction in white blood cells, was observed during cimetidine therapy.
    • The leukopenia resolved upon cessation of cimetidine, indicating a potential adverse drug reaction.

    Implications:

    • This case highlights a potential adverse effect of cimetidine, specifically leukopenia.
  • Clinicians should monitor white blood cell counts in patients receiving cimetidine, particularly those with underlying liver conditions.