Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Study on cefazolin concentration in bone marrow (author's transl)]

M Kawashima

    The Japanese Journal of Antibiotics
    |March 1, 1980
    PubMed
    Summary

    Cefazolin (CEZ) effectively penetrates tibial bone marrow after intramuscular injection, maintaining high concentrations relative to serum levels. This study confirms excellent bone penetration for the antibiotic.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    C4d deposition in the glomeruli and peritubular capillaries associated with transplant glomerulopathy.

    Clinical transplantation·2003
    Same author

    Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study.

    The British journal of dermatology·2003
    Same author

    Real-time interaction of oral streptococci with human salivary components.

    Oral microbiology and immunology·2003
    Same author

    Antileukinate, a hexapeptide inhibitor of CXC-chemokine receptor, suppresses bleomycin-induced acute lung injury in mice.

    Lung·2003
    Same author

    Arginine vasotocin induces bearing down for oviposition in the hen.

    Poultry science·2003
    Same author

    A novel sialyl Lewis(x) analogue attenuates ischemia reperfusion injury in rabbit lung.

    The Thoracic and cardiovascular surgeon·2002

    Area of Science:

    • Pharmacokinetics
    • Bone Marrow Penetration
    • Antibiotic Efficacy

    Context:

    • Assessing antibiotic distribution in bone tissue is crucial for treating osteomyelitis.
    • Cefazolin is a commonly used cephalosporin antibiotic.
    • Understanding drug penetration into bone marrow guides therapeutic strategies.

    Purpose:

    • To quantify Cefazolin (CEZ) concentrations in tibial bone marrow.
    • To determine the ratio of CEZ concentration in bone marrow to serum.
    • To evaluate the penetration capacity of CEZ into bone marrow following intramuscular administration.

    Summary:

    • Cefazolin (CEZ) concentrations were measured in tibial bone marrow at 1, 2, and 3 hours post-intramuscular injection of 1g.
    • Mean CEZ concentrations at 1, 2, and 3 hours were 59.9±10.31, 42.5±7.77, and 33.9±7.75 μg/ml, respectively.
    • Bone marrow to serum ratios consistently exceeded 100% (101.7%, 102.7%, 102.7%), indicating excellent penetration.

    Impact:

    • Demonstrates high Cefazolin bioavailability in bone marrow, supporting its use in bone infections.
    • Provides pharmacokinetic data valuable for optimizing dosing regimens.
    • Highlights the efficacy of Cefazolin in achieving therapeutic concentrations within bone tissue.

    Related Experiment Videos