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Related Experiment Videos

A newly isolated antispasmodic--butylidenephthalide

W C Ko

    Japanese Journal of Pharmacology
    |February 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Butylidenephthalide (BdPh) from Ligusticum wallichii inhibits smooth muscle contractions. While less potent than papaverine, BdPh exhibits a non-specific antispasmodic action with a distinct mechanism.

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    Area of Science:

    • Pharmacology
    • Natural Products Chemistry

    Background:

    • Ligusticum wallichii Franch. is a traditional medicinal herb.
    • Isolation of active compounds from natural sources is crucial for drug discovery.

    Purpose of the Study:

    • To isolate and characterize compounds from Ligusticum wallichii Franch. with potential antispasmodic activity.
    • To compare the antispasmodic effects and mechanisms of butylidenephthalide (BdPh) with papaverine (Pap).

    Main Methods:

    • Isolation and purification of butylidenephthalide (BdPh), ligustilide, and butylphthalide from neutral oil of Ligusticum wallichii Franch.
    • In vitro pharmacological assays using rat uterine contractions and isolated guinea pig ileum, vas deferens, and taenia coli.
    • Assessment of contractile responses to various agonists and comparison with papaverine.

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    Main Results:

    • Butylidenephthalide (BdPh) demonstrated the most potent inhibition of rat uterine contractions induced by prostaglandin F2 alpha, oxytocin, and ACh.
    • BdPh exhibited non-specific antispasmodic activity, inhibiting contractile responses in guinea pig ileum, vas deferens, and taenia coli.
    • BdPh showed similar inhibitory effects on both phasic and tonic contractions, unlike papaverine which selectively inhibited tonic contractions.

    Conclusions:

    • Butylidenephthalide (BdPh) possesses a non-specific antispasmodic action, similar to papaverine.
    • The mechanism of action of BdPh appears to differ from that of papaverine, particularly in its effects on phasic and tonic contractions.