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Related Experiment Videos

Hemoconcentration induced by surface hypothermia in infants

R Y Chen, A E Wicks, S Chien

    The Journal of Thoracic and Cardiovascular Surgery
    |August 1, 1980
    PubMed
    Summary

    Surface hypothermia during cardiac surgery in infants causes a decrease in plasma volume, indicated by rising hematocrit. This suggests plasma may be sequestered or leak into tissues, impacting blood volume regulation.

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    Area of Science:

    • Cardiovascular Physiology
    • Pediatric Cardiac Surgery
    • Hypothermia Research

    Background:

    • Surface hypothermia is used in pediatric cardiac operations.
    • Understanding hematological changes during cooling is crucial for patient management.
    • Previous studies have not fully elucidated plasma volume shifts during induced hypothermia.

    Purpose of the Study:

    • To investigate the effects of surface hypothermia on arterial hematocrit and plasma protein concentration in infants.
    • To explore the underlying mechanisms of observed hematological changes through parallel studies in canine models.

    Main Methods:

    • Measured arterial hematocrit and plasma protein concentration in infants undergoing surface cooling.
    • Conducted parallel studies in normal and splenectomized dogs, measuring plasma volume and red cell volume.
    • Utilized 125I-albumin and 51Cr-erythrocytes for volume measurements in dogs.

    Main Results:

    • Arterial hematocrit progressively increased in infants during surface cooling.
    • Computed plasma volume in infants decreased as body temperature lowered.
    • Plasma protein concentration remained constant throughout the cooling period.

    Conclusions:

    • Progressive decrease in plasma volume during surface hypothermia in infants.
    • Hypothesized plasma sequestration in the circulatory bed or extravasation into interstitial space.
    • Findings highlight the importance of monitoring plasma volume shifts during therapeutic hypothermia.

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