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Updated: Aug 26, 2026

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
Published on: July 3, 2015
Abstract:
This study evaluates the therapeutic significance of those drugs commercially available in foreign countries but not in the United States at the end of 1976. Of 198 drugs reviewed, 14% offered a potential therapeutic advance while 75% appeared to offer little or no advance. Another 10.5% could not be properly evaluated. Division by therapeutic class showed some groups to be disproportionate to the overall percentages. The cardiovascular group had a higher-than-average ratio of drugs that offered major advances, 23%. On the other extreme was the CNS group, for which a review of 37 drugs showed no drugs to represent a major advance. It is concluded that few "breakthrough" drugs in general use in other countries are being kept out of the United States drug market.
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