[The effect of immunoglobulins in experimental peritonitis (author's transl)]

We measured the influence of different drugs on mortality and lung weights in a well known and standardized peritonitis model in rats. The results are: 1. Intraperitoneal injection of immune globulin in high dosage had little effect on our parameters. High mortality and interstitial pulmonary edema were observed. 2. The same results followed injection of 20% human albumin. 3. All animals injected intraperitoneally with a modern antibiotic (Securopen) survived. Interstitial pulmonary edema was observed. 4. The combined injection of an antibiotic and immune globulin (Gamma-Venin) had the best results. None of the rats came down with a lung injection or died.