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Effects of postmenopausal ethinylestradiol treatment on gallbladder bile
Maturitas
|January 1, 1980
Abstract:
Bile composition was studied in three postmenopausal women without evidence of gallstone disease during administration of 50 micrograms of ethinylestradiol daily. The treatment resulted in an increased fraction of cholesterol in gallbladder bile and a shift in the bile acid composition with decreased relative concentration of chenodeoxycholate and increased fraction of cholate. These changes in bile lipid composition might explain the higher incidence of gallstones in women treated with estrogens.
Keywords:
Acceptor CharacteristicsAge FactorsClinical ResearchContraceptionContraceptive Agents, Estrogen--administraction and dosageContraceptive Agents, Estrogen--side effectsContraceptive Agents, Female--administraction and dosageContraceptive Agents, Female--side effectsContraceptive Agents--administraction and dosageContraceptive Agents--side effectsContraceptive Methods--side effectsDemographic FactorsDiseasesEthinyl Estradiol--administraction and dosageEthinyl Estradiol--side effectsFamily PlanningGallbladder DiseasesHuman VolunteersMenopauseOral Contraceptives--side effectsPopulationPopulation CharacteristicsReproductionResearch Methodology