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Increased human red cell cation passive permeability below 12 degrees C

G W Stewart, J C Ellory, R A Klein

    Nature
    |July 24, 1980
    PubMed
    Summary

    Most biological reactions slow when cooled, but red blood cell permeability to potassium (K) and sodium (Na) ions paradoxically increases below 12°C. This suggests a membrane-ordering effect influencing ion transport at low temperatures.

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    Area of Science:

    • Biophysics
    • Cell Biology
    • Membrane Transport

    Background:

    • Biological reaction rates typically decrease with lower temperatures.
    • Cooling is a common method for controlling or halting biological processes.
    • Red blood cell membranes exhibit complex responses to thermal changes.

    Purpose of the Study:

    • To investigate the temperature-dependent permeability of red blood cells to potassium (K) and sodium (Na) ions.
    • To explore paradoxical thermal responses in biological membranes.
    • To provide a thermodynamic interpretation of observed membrane phenomena.

    Main Methods:

    • Experimental measurement of red blood cell K and Na permeability.
    • Controlled cooling of red blood cell samples below 12 degrees C.
    • Thermodynamic analysis of membrane behavior.

    Main Results:

    • A paradoxical increase in red cell K and Na permeability was observed below 12 degrees C.
    • This response contrasts with the typical temperature-dependent decline in reaction rates.
    • The findings suggest a membrane-ordering phenomenon.

    Conclusions:

    • Red blood cell ion permeability exhibits a non-monotonic, paradoxical response to decreasing temperature below 12°C.
    • This phenomenon can be explained by a membrane-ordering effect.
    • Physical measurements support the thermodynamic interpretation of red cell membrane behavior at low temperatures.

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