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Determination and cellular commitment in the embryonic amphibian mesoderm

D Forman, J M Slack

    Nature
    |July 31, 1980
    PubMed
    Summary

    Embryonic development involves multiple stages of commitment, not a single determination event. This research reveals a prolonged period of developmental lability in amphibian mesoderm, impacting pattern formation.

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    Area of Science:

    • Developmental biology
    • Embryology
    • Cell fate determination

    Background:

    • Classical embryology defined 'determination' as a specific developmental stage for cell commitment.
    • Previous definitions lacked clarity on events preceding irreversible cell fate commitment.
    • Understanding early commitment stages is crucial for explaining embryonic pattern formation.

    Purpose of the Study:

    • To investigate the stages of commitment in embryonic development.
    • To determine if organ rudiments undergo multiple commitment stages.
    • To explore the plasticity of the amphibian mesoderm during somitic muscle development.

    Main Methods:

    • Utilized isolation and grafting techniques on amphibian mesoderm.
    • Applied various experimental manipulations to alter developmental pathways.
    • Examined the region destined to become somitic muscle.

    Main Results:

    • Demonstrated multiple, distinguishable stages of commitment for organ rudiments.
    • Identified an extensive period of developmental lability in the amphibian mesoderm.
    • Showed that commitment is not a singular, irreversible event.

    Conclusions:

    • Embryonic commitment occurs over a period with varying degrees of plasticity.
    • The observed lability in mesoderm can explain dorsoventral pattern formation.
    • Revises the classical understanding of developmental determination.

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