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Updated: Aug 14, 2026

Paradigms for Pharmacological Characterization of C. elegans Synaptic Transmission Mutants
Published on: August 19, 2008
Effects of butyrophenone and phenothiazine derivatives on the caudate spindle
Abstract:
Effects of butyrophenone and phenothiazine derivatives on the caudate spindle were examined in gallamine-immobilized cats. Butyrophenone derivatives (haloperidol, trifluperidol and methylperidol; 0.5-8.0 mg/kg i.v.) inhibited the caudate spindle activity in a dose-related manner by 13.5-86.5%. Phenothiazine derivatives (chlorpromazine, perphenazine and trifluoperazine; 0.5-8.0 mg/kg i.v.) inhibited the caudate spindle activity only by 4.0-25.1%. The difference of central action between the two derivatives is discussed.
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