Jove
Visualize
Contact Us

Related Experiment Videos

Lump in the throat

J L Lane

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |August 9, 1980
    PubMed
    Summary
    This summary is machine-generated.

    This study suggests that the "lump in the throat" sensation may stem from lower esophageal sphincter issues. Treatment with metoclopramide and an antacid significantly improved symptoms in most patients.

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The diverse environmental burden of city-scale urban water systems.

    Water research·2015
    Same author

    Measurement of the charge asymmetry in top quark pair production in <i>pp</i> collisions at [Formula: see text] using the ATLAS detector.

    The European physical journal. C, Particles and fields·2015
    Same author

    Search for lepton flavour violation in the <i>eμ</i> continuum with the ATLAS detector in [Formula: see text]<i>pp</i> collisions at the LHC.

    The European physical journal. C, Particles and fields·2015
    Same author

    Measurement of [Formula: see text] production with a veto on additional central jet activity in <i>pp</i> collisions at [Formula: see text] TeV using the ATLAS detector.

    The European physical journal. C, Particles and fields·2015
    Same author

    Measurement of the top quark mass with the template method in the [Formula: see text] channel using ATLAS data.

    The European physical journal. C, Particles and fields·2015
    Same author

    Search for heavy neutrinos and right-handed <i>W</i> bosons in events with two leptons and jets in <i>pp</i> collisions at [Formula: see text] with the ATLAS detector.

    The European physical journal. C, Particles and fields·2015
    Same journal

    SAMA Health Summit Abstracts.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    On behalf of the South African Medical Association (SAMA), The Scientific Committee of the SAMA Health Summit, is pleased to pesent this abstract issue, showcasing the posters and oral presentations delivered at the Summit, which was held from 22-24 May 2026.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    Proceedings of the 2<sup>nd</sup> Data Driven Surgery Conference (DDSC 2025).

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    Clinical practice guidelines for the management of fever and neutropenia in South African children and adolescents with cancer.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    The changing fortunes of the District Health System in SA (1994 - 2020): A retrospective review.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    Thomas Micheal Guntram Ignaz Rehle (1951 - 2025).

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Gastroenterology
    • Otolaryngology

    Background:

    • Common symptoms like throat clearing and a lump sensation often lack clear organic causes.
    • Lower esophageal sphincter (LES) incompetence may lead to esophageal acidity and abnormal motility, causing these symptoms.

    Purpose of the Study:

    • To investigate the efficacy of a treatment regimen targeting cholinergic activity and acidity for the "lump in the throat" syndrome.

    Main Methods:

    • A non-randomized trial involving 54 patients with the characteristic symptom tetrad.
    • Treatment involved metoclopramide (cholinergic agent) and polymethylsiloxane aluminium hydroxide (antacid).

    Main Results:

    • Of 44 patients followed up, 83% reported good symptomatic improvement.
    • 16% of patients showed no change in symptoms.

    Conclusions:

    • The findings support the hypothesis that LES incompetence contributes to the "lump in the throat" syndrome.
    • Further randomized, placebo-controlled trials of metoclopramide are warranted.