Interactions between mercuric chloride and sodium selenite on cultured rat cerebrum

Explants of rat cerebrum in culture were treated with toxic concentration of HgCl2 of 1 x 10(-4) M and with varying concentrations of sodium selenite. Treatment with sodium selenite resulted in a reduced neurotoxicity of HgCl2, a maximal effect being attained at a selenite concentration of 1 x 10(-5) M. However, 1 x 10(-5) M sodium selenite was itself toxic. In in vitro cell systems, the toxicity of either mercury or selenium is decreased in the presence of the other element.