[Effect of sensitization and delayed hypersensitivity reaction on tumor growth in mice]

Mice BALB/c during 8--10 weeks were sensitized by percutaneous injections of BCG vaccine or living B-243 staphylococci weekly, and after 10 days they were inoculated isogenic adenocarcinoma "Akatol". Compared with the control animals the tumor growth was found to be retarded. A more considerable retardation of the growth and in 50% the complete tumor regression was noted in sensitized mice, which repeatedly, since the day of inoculation, were injected subcutaneously or intratumorously alttuberculin or staphylococcic phagolysate, respectively. A gain of the tumor mass was associated with concomitant lessening of skin edema in response to test-allergen injection. Injections of alttuberculin in BCG-sensitized mice C3H/He contribute to an increased cytotoxicity of peritoneal macrophages against the cells of mammary gland isogenic tumor.