Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Interaction of digoxin and quinidine]

K O Haustein, G Oltmanns

    Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
    |February 15, 1980
    PubMed
    Summary

    Concurrent quinidine use significantly elevates plasma digoxin levels in patients with congestive heart failure. Reduced digoxin dosage is recommended to manage this drug interaction and ensure patient safety.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Imaging of mesothelioma of tunica vaginalis testis.

    European radiology·2015
    Same author

    Relation of impaired interorgan communication and parasympathetic activity in chronic heart failure and multiple-organ dysfunction syndrome.

    Journal of critical care·2014
    Same author

    Cardiac resynchronization therapy using dual-site left ventricular pacing improves severe left ventricular dysfunction due to ischemic cardiomyopathy and permanent right ventricular apical pacing.

    International journal of cardiology·2012
    Same author

    Leiomyosarcoma of the inferior vena cava extending into the right atrium. A rare differential diagnosis of a right atrial tumor with fatal outcome.

    Herz·2012
    Same author

    Spigelian-cryptorchidism syndrome: a case report and discussion of the basic elements in a possibly new congenital syndrome.

    Pediatric surgery international·2010
    Same author

    Changes in hemorheological and biochemical parameters following short-term and long-term smoking cessation induced by nicotine replacement therapy (NRT).

    International journal of clinical pharmacology and therapeutics·2004

    Area of Science:

    • Pharmacology
    • Cardiovascular Medicine

    Context:

    • Investigating drug interactions in patients with cardiovascular diseases.
    • Focus on digitalization for acute congestive heart failure management.

    Purpose:

    • To assess the impact of quinidine on plasma digoxin levels and excretion.
    • To determine appropriate digoxin dosage adjustments when co-administered with quinidine.

    Summary:

    • Studied 5 patients with cardiovascular diseases requiring digoxin for congestive heart failure.
    • One patient concurrently received quinidine, exhibiting a 2-2.5 fold increase in plasma digoxin levels.
    • Digoxin excretion showed a slight increase in the quinidine-treated patient.

    Impact:

    • Recommends halving the digoxin dosage when used concurrently with quinidine.
    • Highlights the importance of monitoring digoxin levels during combined therapy.
    • Informs clinical practice for optimizing heart failure treatment and minimizing adverse events.

    Related Experiment Videos