Relationships between excessive blood cell proliferation and neural crest cells in suckling mice

In suckling mice injected intraperitoneally with mitomycin C, endotoxin, hydrocortisone and androgen, excessive, proliferation of blood cells was found in the blood vessels and in the sites where neural crest cells and non-staining spindle shaped neural crest cells may be present. It is speculated that these phenomena may be related with the cell surface properties of neural crest cells in the G1 phase of the cell cycle through the system mediated by cyclic AMP, and that the non-staining spindle-shaped neural crest cells in the blood vessels may be the hemopoietic stem cells.