Intraepithelial neoplasia and carcinoma in the vaginal vault

An 11-year biopsy material from the vagina is presented. The indication for taking the 370 vaginal biopsies was abnormal cytology, polyps, or suspicion of tumor tissue. The material was found to include 10 cases of intraepithelial neoplasia, viz. 4 primary, 6 secondary, and 2 late cases of secondary invasive carcinoma. The interval between the primary and secondary diagnosis ranged from 7 months to 19 years. It is concluded that the risk of secondary changes in the vaginal mucosa is slight, but cytological follow-up is recommended.