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Related Experiment Videos

Nerve endings in the human prostate

A Vaalasti, A Hervonen

    The American Journal of Anatomy
    |January 1, 1980
    PubMed
    Summary

    Researchers identified three types of nerve endings in the human prostate, including a novel type with large granular vesicles. These nerve endings only innervate smooth muscle cells, not epithelial cells.

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    Area of Science:

    • Urology
    • Neuroscience
    • Cell Biology

    Background:

    • The human prostate's innervation is crucial for its function.
    • Understanding nerve endings aids in diagnosing and treating prostate conditions.

    Purpose of the Study:

    • To investigate the ultrastructure of human prostate nerve endings.
    • To classify these nerve endings and identify their targets.

    Main Methods:

    • Utilized glutaraldehyde-OsO4 and KMnO4 fixation techniques.
    • Examined nerve endings via electron microscopy.
    • Classified axons based on vesicle size and content.

    Main Results:

    • Identified three distinct categories of nerve endings.
    • Discovered a novel axon type with predominantly large granular vesicles.
    • Confirmed synaptic contacts exclusively on smooth muscle cells.
    • Found no evidence of epithelial innervation.

    Conclusions:

    • The human prostate contains diverse nerve endings, including a previously undescribed type.
    • Innervation is restricted to smooth muscle, suggesting roles in muscle function.
    • Further research is needed to determine the function and transmitters of these axon types.

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