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Ankyloblepharon filiforme adnatum: congenital eyelid-band syndromes
American Journal of Diseases of Children (1960)
|August 1, 1980
Insights
Congenital eyelid bands, known as ankyloblepharon filiforme adnatum (AFA), were observed in three infants with cleft lip and palate. A new classification for AFA is proposed to assist with genetic counseling.
Area of Science:
- Ophthalmology
- Genetics
- Pediatric Surgery
Background:
- Ankyloblepharon filiforme adnatum (AFA) is a rare congenital condition characterized by eyelid adhesion.
- The association between AFA and orofacial clefts is infrequently reported, necessitating further investigation into potential shared etiologies.
- Understanding the spectrum of AFA presentation is crucial for accurate diagnosis and management.
Observation:
- Three infants presented with congenital eyelid bands (AFA) concurrently with cleft lip and palate.
- This observation suggests a potential link or syndromic association between AFA and clefting disorders.
- Detailed clinical examination revealed specific characteristics of the eyelid bands in these cases.
Findings:
- A comprehensive literature review of AFA cases was conducted.
- A novel classification system for the clinical variations of AFA has been developed based on the review.
- This proposed classification categorizes AFA into distinct types, aiding in phenotype description.
Implications:
- The new AFA classification may improve the accuracy of genetic counseling for affected families.
- Identifying distinct AFA subtypes could lead to a better understanding of the underlying genetic factors.
- This work contributes to the clinical knowledge base for rare congenital anomalies and their management.
Abstract:
Three infants had congenital eyelid bands, ankyloblepharon filiforme adnatum (AFA), in association with cleft lip and palate. A review of the literature of all previously reported cases of AFA was performed and a new classification of the various clinical types of AFA is proposed. This new classification should aid in genetic counseling.