[EEG effects of diazepam. Studies on 16 patients (author's transl)]

Recordings of the electrical activity of the brain were obtained by using conventional EEG and computerized EEG. Both methods of recording have been used as an indicator of the cerebral condition before and after intravenous premedication with Diazepam 20 mg. Two groups of patients were studied. The first group consisted of younger patients (Gr. A n = 8), the other of geriatric patients (Gr. B n = 8). Evaluation of EEG and CEEG was done by to experienced electroencephalographers separately. Interpretations of both methods were compared and found to correspond. In group A variations found in the baseline EEG were within normal limits and corresponded with those seen in the average population. In group B 67.5% of the examined EEG's showed variaions from normal. After intravenous premedication with Diazepam both groups of patients showed changes in the electrogrm as well as in the clinical condition. Changes in group B were more marked. Characteristic of EEG changes induced by Diazepam was a high increase of activity of beta-waves from 12-20 Hz and decrease of alpha-waves. These alterations were seen together with the clinical signs of psychical indifference and effects of sedation. A temporary activation of frequencies between 4-8 Hz was also found which indicates sleep.