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Histamine flare, a neurovascular response

J Rebhun, J Botvin

    Annals of Allergy
    |August 1, 1980
    PubMed
    Summary

    The histamine flare response requires intact sympathetic nervous system pathways. Spinal cord injury disrupts these connections, impairing skin reactions to histamine.

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    Area of Science:

    • Neuroscience
    • Dermatology
    • Physiology

    Background:

    • The histamine flare response is a complex physiological reaction involving the skin and nervous system.
    • Sympathetic innervation plays a crucial role in modulating vascular responses, including the histamine flare.

    Purpose of the Study:

    • To investigate the role of sympathetic innervation in the histamine flare response.
    • To determine if spinal cord injury affects the integrity of pathways controlling the histamine flare.

    Main Methods:

    • Assessed skin responses to exogenous histamine in patients with spinal cord injury.
    • Correlated the presence or absence of skin responses with the neurological status of the patients.

    Main Results:

    • 75% of patients with spinal cord injury exhibited a lack of skin response to histamine.
    • This suggests a significant impairment in the histamine flare mechanism following spinal cord injury.

    Conclusions:

    • The integrity of sympathetic innervation and central nervous system connections is essential for a normal histamine flare response.
    • Spinal cord injury disrupts these critical pathways, leading to diminished or absent skin reactions to histamine.

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