[Bacteriological and pathomorphological control of the effectiveness of the therapy of experimental pyocyanic burn...

Bacteriological and pathomorphological characteristics of experimental pyocyanic burn infection in noninbred albino mice are presented. The model was used for comparative investigation of the chemotherapeutic efficacy of quinoxidin, dioxidin, carbenicillin and gentamicin. The chemotherapeutic efficacy of quinoxidin and dioxidin was shown to be higher than that of carbenicillin and gentamicin with respect to both the bacteriological criteria and the pathomorphological indices. Carbenicillin was inferior to gentamicin in the results of the bacteriological investigation and superior to it with respect to the data of the pathomorphological study. Thus, quinoxidin, dioxidin and to a less extent carbenicillin prevented the development of the purulent inflammatory foci in the internal organs, whereas the use of gentamicin resulted in a slower rate of the inflammatory process organization in the kidneys of the experimental animals.