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Susceptibility of Bacterium actinomycetem comitans to 45 antibiotics

U Höffler, W Niederau, G Pulverer

    Antimicrobial Agents and Chemotherapy
    |June 1, 1980
    PubMed

    Insights

    Bacterium actinomycetem comitans (Actinobacillus actinomycetem-comitans) showed susceptibility to tetracyclines and chloramphenicol, but resistance to some penicillins. Tetracyclines and chloramphenicol were the most effective antimicrobial agents.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Actinobacillus actinomycetem-comitans is an important pathogen.
    • Understanding its antimicrobial susceptibility is crucial for effective treatment.

    Purpose of the Study:

    • To determine the in vitro antimicrobial susceptibility profile of Actinobacillus actinomycetem-comitans.
    • To identify effective antimicrobial agents against this bacterium.

    Main Methods:

    • Minimal inhibitory concentrations (MICs) were determined for 45 antimicrobial agents.
    • Fourteen strains of Actinobacillus actinomycetem-comitans were tested.

    Main Results:

    • All strains were susceptible to tetracyclines and chloramphenicol.
    • Resistance was observed to lincomycins, penicillins, cephalosporins, and nitroimidazoles in some strains.
    • Tetracycline, rolitetracycline, methacycline, minocycline, chloramphenicol, and cotrimoxazole exhibited the lowest MICs.

    Conclusions:

    • Tetracyclines and chloramphenicol are effective agents against Actinobacillus actinomycetem-comitans.
    • Antimicrobial stewardship should consider these findings to guide therapy.

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