Human percutaneous penetration of hydrocortisone: the vulva

Percutaneous penetration of 14C hydrocortisone through normal vulvar skin (labia majora) was measured in six subjects and compared with that of the forearm. Of the topically applied hydrocortisone 7.7% penetrated vulvar skin whereas 1.3% penetrated forearm skin. This regional variation of percutaneous penetration may have toxicologic and therapeutic significance.