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Updated: Aug 18, 2026
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Depletion of Specific Cell Populations by Complement Depletion
Published on: February 5, 2010
Studies of murine complement. Correlation of hypocomplementemia with other disease parameters in individual NZB/W
Arthritis and Rheumatism
|August 1, 1980
Abstract:
We have utilized a new assay for murine complement components to explore the relationship of complement titers to other parameters of disease activity in individual NZB/W female mice. Titers had fallen significantly by 6 months of age, concomitantly with the appearance of antiDNA in serum and of C3 and immunoglobulin in renal glomeruli. The period of hypocomplementemia antedating proteinuria was extremely variable. Heat stable anti-complementary material was found in serum from older NZB/W mice.
