The effects of polymer-solvent compositions on the formation of collodion membrane artificial cells

This study is an attempt to analyze the various polymer-solvent compositions for preparing collodion membrane artificial cells for biomedical applications. Cellulose nitrate was disolved in different mixtures of alcohol-ether solutions and used for microencapsulation. The most optimal solvent solution consisted of 4 g% cellulose nitrate in 17.5% (volume) alcohol and 82.5% (volume) ether. The urease microcapsules prepared this way showed no leakage of enzyme under test conditions. Having established the optimal polymer-solvent compositions, an easier and more reproducible procedure has been established for preparing collodion membrane artificial cells.