Related Experiment Videos
[Effect of hemopoietic regeneration on the course of a systemic "graft vs host" reaction]
Acute hemorrhage of varying severity was produced in (CBA x C57BL/6)F1 hybrids. Then it was followed by the induced systemic graft-versus-host reaction (GVHR). The increased intensity of the hemorrhage made the course of the systemic GVNR more severe. The 10th day after GVHR induction no significant differences were found in the peripheral blood of experimental or control animals. However, the hybrids demonstrated a significant rise in the number of exogenic stem cells in the spleens during hemopoietic regeneration and diminution of the immunocompetence of splenic T cells.
Acute hemorrhage of varying severity was produced in (CBA x C57BL/6)F1 hybrids. Then it was followed by the induced systemic graft-versus-host reaction (GVHR). The increased intensity of the hemorrhage made the course of the systemic GVNR more severe. The 10th day after GVHR induction no significant differences were found in the peripheral blood of experimental or control animals. However, the hybrids demonstrated a significant rise in the number of exogenic stem cells in the spleens during hemopoietic regeneration and diminution of the immunocompetence of splenic T cells.