Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sequential clinical trials in cancer research

S L George

    Cancer Treatment Reports
    |February 1, 1980
    PubMed
    Summary

    Decisions to stop clinical trials involve ethical considerations, not just statistics. Proper statistical methods are crucial for sequential analyses to avoid misinterpretation of results.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Intermetallic and dispersoid structures in AA3104 aluminium alloy during two-step homogenisation.

    Scientific reports·2024
    Same author

    Novel therapeutic strategies targeting telomere maintenance mechanisms in high-risk neuroblastoma.

    Journal of experimental & clinical cancer research : CR·2020
    Same author

    Escalation of daunorubicin and addition of etoposide in the ADE regimen in acute myeloid leukemia patients aged 60 years and older: Cancer and Leukemia Group B Study 9720.

    Leukemia·2011
    Same author

    Quality of life after pancreatectomy.

    Annals of surgical oncology·2006
    Same author

    P-glycoprotein (Pgp) modulation in untreated acute myeloid leukemia (AML): Cancer and Leukemia Group B (CALGB) trials in younger and older adults.

    Annals of hematology·2004
    Same author

    The unmet needs of young people who have had a stroke: results of a national UK survey.

    Disability and rehabilitation·2002

    Area of Science:

    • Clinical Trials
    • Biostatistics
    • Medical Ethics

    Background:

    • Clinical trial termination decisions are complex, balancing ethical imperatives with statistical data.
    • Unlike industrial quality control, human subject research prioritizes ethical stopping rules over purely statistical ones.
    • Investigators must understand the sequential nature of clinical trial analysis.

    Purpose of the Study:

    • To discuss the ethical and statistical considerations in terminating clinical trials.
    • To highlight the challenges and limitations in applying sequential analysis techniques in clinical research.
    • To provide historical context and reasons for the underutilization of sequential trial designs.

    Main Methods:

    • Review of historical developments in sequential trial methodology.
    • Classification of different types of sequential clinical trials.
    • Analysis of practical and theoretical barriers to sequential trial implementation.

    Main Results:

    • Statistical considerations are important but secondary to ethical factors in trial termination.
    • Standard statistical measures like 'P values' are inappropriate for repeated analyses of accumulating data.
    • Sequential analysis techniques face significant practical and theoretical hurdles in clinical settings.

    Conclusions:

    • There is a need for improved statistical theory and methods for sequential clinical trials.
    • Ethical considerations heavily influence clinical trial stopping decisions.
    • Wider adoption of sequential trial designs is hindered by practical and theoretical difficulties.

    Related Experiment Videos