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The caveolae in rabbit sinus node and atrium

M Masson-Pévet, D Gros, E Besselsen

    Cell and Tissue Research
    |January 1, 1980
    PubMed
    Summary
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    Caveolae, or membrane vesicles, are abundant in rabbit heart sinus node and atrial cells, significantly increasing plasma membrane surface area. Their specific function remains unclear, but pinocytosis is unlikely.

    Area of Science:

    • Cardiovascular Biology
    • Cellular Ultrastructure

    Background:

    • Caveolae are common membrane invaginations in muscle cells.
    • Their presence and function in cardiac pacemaker cells are not well understood.

    Purpose of the Study:

    • To investigate the abundance and characteristics of caveolae in rabbit sinus node and atrial cells.
    • To determine the impact of caveolae on plasma membrane surface area in these cells.

    Main Methods:

    • Analysis of fixed tissue sections.
    • Freeze-fracture electron microscopy of cardiac tissue.

    Main Results:

    • Caveolae are highly numerous in sinus node cells and abundant in atrial cells.
    • Caveolae increase plasma membrane surface area by 115% in sinus node cells and 56% in atrial cells.

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  • Caveolar membranes have significantly fewer intramembranous particles compared to the general plasma membrane.

    • Conclusions:

    • Caveolae are a prominent feature of rabbit cardiac pacemaker and atrial cells.
    • Their unique composition suggests specialized roles beyond simple membrane surface area expansion.
    • A pinocytotic function for these caveolae is unlikely.