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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Acebutolol and hydrochlorothiazide in essential hypertension

J Nadeau, R I Ogilvie, J Ruedy

    Clinical Pharmacology and Therapeutics
    |September 1, 1980
    PubMed

    Insights

    Acebutolol (ABL) effectively lowers blood pressure in patients with essential hypertension. Unlike hydrochlorothiazide (HCT), ABL also reduces heart rate and tension-time index without adverse effects on potassium or uric acid.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Essential hypertension is a common condition.
    • Peripheral renin activity can influence treatment choices.

    Purpose of the Study:

    • To compare the efficacy and effects of Acebutolol (ABL) and hydrochlorothiazide (HCT) in patients with mild to moderate essential hypertension and low or normal peripheral renin activity.

    Main Methods:

    • Patients with mild to moderate essential hypertension and low/normal renin activity were treated with either ABL or HCT.
    • Blood pressure, heart rate, and peripheral renin activity were monitored.
    • Adverse effects on serum potassium and uric acid were assessed.

    Main Results:

    • Both ABL and HCT reduced supine blood pressure effectively.
    • ABL decreased heart rate, while HCT increased it.
    • Tension-time indices were lower with ABL due to reduced heart rate.
    • ABL did not negatively impact serum potassium or uric acid levels.
    • Peripheral renin activity increased with HCT but remained stable or decreased with ABL.

    Conclusions:

    • Acebutolol is as effective as hydrochlorothiazide in lowering blood pressure for this patient group.
    • ABL offers additional benefits by reducing heart rate and tension-time index.
    • ABL presents a favorable safety profile regarding serum electrolytes and uric acid.

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