[Acebutolol in coronary heart disease: an ergometric double-blind study (author's transl)]

In 20 patients with coronary heart disease and typical changes in the exercise ECG (evidence of myocardial hypoxia), which disappeared completely on second ergometry after isosorbid dinitrate, the effect of a single dose of 400 mg acebutolol (Prent) was tested on exercise. Ergometrically induced cardiac work was significantly reduced in all patients, compared with leg exercise (little change in lower, more marked change in the higher ranges of exercise) so that repeat ergometry at the same ergometric level of exercise produced neither signs of hypoxia nor angina. There were no significant changes after a placebo.