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Multicomponent diffusion in the lung

H K Chang

    Federation Proceedings
    |August 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Multicomponent diffusion physics is key to respiratory physiology. Fick's law applies to normal breathing but fails with helium or hyperbaric conditions.

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    Area of Science:

    • Respiratory Physiology
    • Gas Diffusion Physics

    Background:

    • Breathing involves multiple gases, making multicomponent diffusion physics relevant to respiratory physiology.
    • Existing studies cover both equimolar and nonequimolar diffusion principles.

    Purpose of the Study:

    • To review fundamental principles and key studies in multicomponent diffusion relevant to respiratory physiology.
    • To emphasize nonequimolar diffusion due to the lung's nature as an open-system exchanger.
    • To present a verified mathematical model for studying diffusion in the alveolar spaces.

    Main Methods:

    • Review of fundamental principles and important studies in multicomponent diffusion.
    • Presentation of a mathematical model for nonequimolar diffusion.
    • Application of the model to study ternary diffusion and determine effective diffusion coefficients in alveolar spaces.

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    Main Results:

    • Fick's law remains valid for normal air breathing under normal pressure with tracer inert gases.
    • Fick's law is not applicable when helium is used as a carrier gas.
    • Fick's law breaks down under extreme hyperbaric conditions.

    Conclusions:

    • Multicomponent diffusion is crucial for understanding respiratory physiology.
    • A validated mathematical model aids in studying alveolar gas exchange.
    • Deviations from Fick's law occur under specific conditions like helium use or hyperbaria.