Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Campylobacter enteritis in young mice

D S Madge

    Digestion
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Campylobacter infection in young mice impairs D-glucose and D-galactose absorption in the small intestine. However, older mice showed no significant changes in nutrient absorption after infection.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of the bipyridilium herbicides, diquat and paraquat, on in vivo hexose absorption and fluid transfer in adult mice.

    General pharmacology·1982
    Same author

    The effects of pentachlorophenol on intestinal solute absorption and fluid transfer in mice.

    General pharmacology·1981
    Same author

    Effects of a polychlorinated biphenyl, Kanechlor 400, on intestinal solute transport and fluid transfer in mice.

    General pharmacology·1979
    Same author

    Bacillus cereus-induced malabsorption in young mice.

    Digestion·1978
    Same author

    Action of dibenzofurans and naphthalenes on intestinal solute transport and fluid transfer in mice.

    General pharmacology·1978
    Same author

    Polychlorinated terphenyls and intestinal transport in mice.

    General pharmacology·1977

    Area of Science:

    • Microbiology
    • Gastroenterology
    • Animal Models

    Background:

    • Campylobacter species are common causes of bacterial gastroenteritis in humans.
    • Age-related differences in immune response and intestinal function may influence infection outcomes.

    Purpose of the Study:

    • To investigate the impact of Campylobacter infection on small intestinal solute absorption and fluid transfer in young versus aged mice.
    • To determine if age influences the susceptibility of intestinal absorptive functions to bacterial pathogens.

    Main Methods:

    • Oral inoculation of young (4-6 weeks) and old (24-26 weeks) mice with two strains of pathogenic Campylobacter.
    • In vitro measurement of D-glucose and D-galactose absorption and fluid transfer in small intestinal segments 7 days post-inoculation.

    Related Experiment Videos

    Main Results:

    • Young mice infected with Campylobacter exhibited significantly reduced D-glucose and D-galactose absorption.
    • D-glucose absorption was impaired in the distal four-fifths of the small intestine in young infected mice.
    • No significant alterations in solute absorption or fluid transfer were observed in old infected mice.

    Conclusions:

    • Young mice are more susceptible to the detrimental effects of Campylobacter infection on small intestinal nutrient absorption.
    • Age appears to confer a degree of protection against the intestinal absorptive dysfunction caused by Campylobacter.