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Updated: Aug 13, 2026
06:21
Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration
Published on: April 27, 2018
Glomerulonephritis and virus-like particles associated with prostatic cancer
Human Pathology
|July 1, 1980
Summary
Hormonal therapy for prostate cancer can cause nephrotic syndrome. This condition, linked to tumor antigen-antibody complexes, may improve with reduced estrogen doses and immune cell activity.
Area of Science:
- Nephrology
- Oncology
- Immunology
Background:
- Prostate cancer patients undergoing hormonal therapy can develop nephrotic syndrome.
- Estrogen therapy dosage correlated with nephrotic syndrome severity and proteinuria.
Observation:
- Renal biopsy revealed membranoproliferative glomerulonephritis with subendothelial electron dense deposits.
- Immunofluorescence confirmed complement deposition in glomeruli.
- Glomeruli contained microspherical particles similar to those in prostate cancer.
Findings:
- Circulating tumor antigen-antibody complexes are implicated in causing glomerulonephritis.
- Severity of glomerulonephritis correlated with soluble antigen release from tumor destruction.
- Glomerular endothelial cells showed evidence of immune complex resorption.
Implications:
- Hormonal therapy-induced nephrotic syndrome in prostate cancer is likely immune-complex mediated.
- Reversibility of nephrotic syndrome may be due to endothelial cell phagocytosis of immune complexes.
- The role of virus-like particles in the pathogenesis remains undetermined.
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