[Problems in diagnostics of histoplasmosis (author's transl)]

This report deals with three observations of Histoplasma mycosis (one acquired in Western Africa - large cell form; two in the USA - classical form) which were diagnosed from 10 to 35 years after primary infection. The laboratory diagnosis was based on immunological, histopathological and clinico-epidemiological data, since in none of the cases material was available for mycological culture. The histoplasmin skin test is considered to be the most sensitive procedure. A positive outcome may support other evidence or suspicion and may deliver an valid clue - particularly among individuals from non-endemic areas-to consider the possibility of Histoplasma infection. The demonstration of serum antibodies may assist in establishing a correct diagnosis in such cases.