Molecular characterization of HLA-A, B homologues in owl monkeys and other nonhuman primates

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P Parham, H L Ploegh

    Immunogenetics
    |January 1, 1980
    PubMed

    Mouse anti-HLA-A, B monoclonal antibodies have been used to study the homologues of HLA-A, B antigens in other primate species. Immunoprecipitates of primate histocompatibility antigens from extracts of radioactively labeled lymphocytes were analyzed by SDS-polyacrylamide electrophoresis. Primate histocompatibility antigens appear to have similar molecular structure to human HLA antigens. Owl monkeys, which react polymorphically with some monomorphic anti-HLA antibodies, showed biochemical differences which correlated with the serological polymorphism. An antibody (W6/32) which only reacts with the HLA/beta 2-microglobulin complex in humans and not with the free HLA heavy chain has the reverse specificity in some owl monkeys.

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