Characteristics of proline oxidase in rat tissues

In adult rats the activity of proline oxidase is high in the liver and kidney and moderate in the brain and heart, but it is not detectable in the lung, skeletal muscle, spleen, or small intestine. The activity in the liver is 1.5 times higher in females than males. Administration of estrogen to male rats increased the activity in liver and decreased that in kidney. Administration of a high protein diet increased the activity in the liver only. Administration of hydrocortisone or dexamethasone did not affect the activity in any tissue.