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Two-dimensional maps of the cerebral cortex

D C Van Essen, J H Maunsell

    The Journal of Comparative Neurology
    |May 15, 1980
    PubMed
    Summary
    This summary is machine-generated.

    This study presents a novel method for creating 2D unfolded cortical maps from histological sections. These maps accurately represent the entire cerebral cortex, aiding in the study of brain organization and function.

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    Area of Science:

    • Neuroscience
    • Comparative Anatomy

    Background:

    • Mapping the complex three-dimensional structure of the cerebral cortex is challenging.
    • Histological sections provide detailed anatomical information but require sophisticated reconstruction methods.

    Purpose of the Study:

    • To develop a procedure for creating accurate two-dimensional, unfolded representations of the entire cerebral cortex.
    • To demonstrate the utility of these cortical maps for displaying functional subdivisions and measuring cortical areas.

    Main Methods:

    • Utilizing outlines from histological sections to reconstruct a flattened cortical surface.
    • Developing a standardized mapping technique applicable across different hemispheres and species.

    Main Results:

    Related Experiment Videos

  • Generated single, unified cortical maps representing an entire hemisphere.
  • Demonstrated similarity in size, shape, and organization across maps from the same species.
  • Confirmed that map configuration is independent of the sectioning plane.
  • Showcased applications in macaque and cat brains, accurately measuring cortical subdivisions (within 20% of actual surface area).

    • Conclusions:

    • The described procedure provides a reliable method for creating accurate, two-dimensional unfolded cortical maps.
    • These maps facilitate the study of cortical organization, functional localization, and precise area measurements.
    • The technique offers a valuable tool for comparative neuroanatomy and functional brain mapping.