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The human pineal gland in malignancy

E Tapp

    Journal of Neural Transmission
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Pineal gland weight and calcification vary by age, sex, and cause of death. Histological analysis reveals minor age-related cellularity decrease and increased fibrosis/gliosis in females, with trauma/burns correlating to higher gland weight.

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    Area of Science:

    • Anatomy and Histology
    • Biogeochemistry
    • Pathology

    Background:

    • The pineal gland's weight, calcification, and cellular characteristics are influenced by various factors.
    • Understanding these variations is crucial for interpreting its role in aging and disease.

    Purpose of the Study:

    • To quantify the weight and calcification of human pineal glands.
    • To histologically assess cellularity, nuclear size, and degeneration.
    • To investigate correlations between pineal gland characteristics and demographic/clinical factors.

    Main Methods:

    • Measurement of weight and calcification in 500 human pineal glands.
    • Histological examination for cellularity, pineocyte nuclear size, and degeneration.
    • Statistical analysis of gland characteristics in relation to age, sex, and cause of death.

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    Main Results:

    • Pineal gland weight and calcification exhibit differences based on age and sex.
    • A slight decrease in cellularity with age was observed, with increased fibrosis and gliosis in females.
    • Gland weight was higher in individuals deceased from trauma and burns, and larger in breast carcinoma and melanoma patients compared to sarcoma patients.

    Conclusions:

    • Age, sex, and cause of death significantly influence pineal gland weight and calcification.
    • Histological changes in the pineal gland are subtle with aging.
    • Specific conditions like trauma, burns, breast carcinoma, and melanoma are associated with altered pineal gland size.