[Correction of nitrogen metabolic disorders in the myocardium in experimental ischemia]

Coronary occlusion was carried out in 58 dogs in an acute experiment and the content of ammonia and urea was studied in venous blood draining directly from the zone of ischemia. Early increase in the concentration of free ammonia in the zone of ischemia was revealed. The administration of l-aspartic acid, potassium asparaginate, magnesium asparaginate, and glutamic acid led to intensification of urea-producing processes in the myocardium and reduction in hyperammoniemia and the degree of ischemic damage to the myocardium.