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[alpha-lipoprotein cholesterol and its variability in ischemic heart disease]
Insights
Alpha-cholesterol levels fluctuate in patients with ischemic heart disease, particularly those with hyperlipoproteinemia. Lower alpha-cholesterol and higher triglyceride levels are linked in these patients.
Area of Science:
- Cardiology
- Lipid Metabolism
Background:
- Ischemic heart disease (IHD) is a significant health concern.
- Lipid profiles, including cholesterol and triglycerides, play a crucial role in cardiovascular health.
- Understanding alpha-cholesterol dynamics in IHD patients is vital for risk assessment.
Purpose of the Study:
- To examine alpha-cholesterol fluctuations in patients with ischemic heart disease.
- To compare alpha-cholesterol levels in IHD patients with normolipidemia and various hyperlipoproteinemia types against healthy populations.
- To investigate the relationship between alpha-cholesterol and other blood lipid fractions, including triglycerides.
Main Methods:
- Repeated examination of 150 patients with ischemic heart disease.
- Categorization of patients based on normolipidemia and hyperlipoproteinemia types (IIa, IIb, IV).
- Analysis of blood lipid fractions, including alpha-cholesterol, total cholesterol, and triglycerides.
Main Results:
- Alpha-cholesterol levels showed fluctuations in IHD patients, most pronounced in types IIb and IV hyperlipoproteinemia.
- IHD patients exhibited lower alpha-cholesterol content compared to population test results.
- A greater disparity was observed in the percentage of total cholesterol from alpha-lipoproteins and the cholesterol atherogenic index in IHD patients.
- Reduced alpha-cholesterol was found in both hyperlipoproteinemia and normolipidemia.
- A negative correlation was identified between alpha-cholesterol levels and blood triglyceride content.
Conclusions:
- Alpha-cholesterol levels are reduced and fluctuate in ischemic heart disease patients.
- The cholesterol atherogenic index is a sensitive indicator in IHD patients.
- Reduced alpha-cholesterol is associated with elevated triglyceride levels, highlighting its importance in IHD pathogenesis.
Abstract:
The authors conducted a repeated examination of 150 patients suffering from ischemic heart disease with normolipidemia and types IIa, IIb and IV hyperlipoproteinemia. The content of alpha-cholesterol in these patients tended to fluctuate, just as the content of other blood lipid fractions. Its fluctuations were most marked in types 11b and IV hyperlipoproteinemia. Comparison of the alpha-cholesterol content in patients with ischemic heart disease with the results of population tests confirmed the information on its lower level in patients. A still greater difference between patients and healthy individuals was revealed when the percentage of total cholesterol for which alpha-lipoproteines accounted and the value of the cholesterol atherogenic index were compared. Reduced concentration of alpha-cholesterol was encountered not only in hyperlipoproteinemia, but also in normolipidemia. The level of alpha-cholesterol had a negative correlative connection with the content of triglycerides in the blood.