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Updated: Jun 29, 2026

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells
Published on: July 16, 2011
[Erythrocyte balance during 182 days of hypokinesia]
Abstract:
A prolonged head-down tilt resulted by the end of the second month in a significant decrease in the circulating blood volume at the expense of plasma and erythrocyte volumes. One of the factors that caused a reduction in the erythrocyte volume was their survival time shortening. The fact that during the rest four hypokinetic months there was no further decline in the erythrocyte count was attributed to adaptive developments: increase of bone marrow production and rate of differentiation of erythroid elements. Exercises used as a countermeasure could slightly counteract the adverse effects of head-down tilt.
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