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A miniature fiber optic pH sensor for physiological use

S R Goldstein, J I Peterson, R V Fitzgerald

Journal of Biomechanical Engineering

|May 1, 1980

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A novel flexible fiber optic pH probe was developed for physiological monitoring. This innovative device accurately measures pH in various conditions, showing promise for clinical applications.

Area of Science:

Biomedical Engineering
Analytical Chemistry
Medical Devices

Background:

Accurate and reliable pH monitoring is crucial for physiological assessment.
Existing pH measurement technologies may have limitations in flexibility and invasiveness for certain applications.

Purpose of the Study:

To develop and evaluate a novel flexible fiber optic pH probe for physiological use.
To assess the probe's accuracy and performance compared to standard methods in various environments.

Main Methods:

Development of a 0.4-mm diameter flexible fiber optic probe using two plastic strands.
Utilizing a dye indicator within a sealed cellulosic hollow fiber permeable to hydrogen ions.
Employing an electronic module for illumination, light sensing, signal processing, and optical density measurements at 560 nm and red wavelengths.

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Main Results:

The fiber optic probe demonstrated high agreement with standard glass pH electrodes (within 0.01 pH units in buffers).
Excellent accuracy was maintained in heparinized dog blood in vitro (within 0.017 pH units).
Successful in vivo performance was achieved during implantation in a sheep's jugular vein.

Conclusions:

A flexible fiber optic pH probe has been successfully developed and validated.
The probe shows significant potential for accurate and reliable physiological pH monitoring.
This technology offers a promising alternative for applications requiring flexible and minimally invasive pH sensing.