Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development of 'primary' hyperparathyroidism during lithium therapy: longitudinal study

C Christiansen, P C Baastrup, I Transbøl

    Neuropsychobiology
    |January 1, 1980
    PubMed
    Summary

    Lithium treatment in manic depressive patients led to decreased bone mineral content and increased parathyroid hormone, calcium, and magnesium levels. This suggests lithium may induce mild primary hyperparathyroidism.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Measurement of a more stable region of osteocalcin in serum by ELISA with two monoclonal antibodies.

    Clinical chemistry·1995
    Same author

    Body composition and serum lipids in female runners: influence of exercise level and menstrual bleeding pattern.

    European journal of clinical investigation·1995
    Same author

    Changes in the carboxyl-terminal propeptide of type I procollagen and other markers of bone formation upon five days of bed rest.

    Bone·1995
    Same author

    Measurement of bone mineral density.

    Calcified tissue international·1995
    Same author

    Impact of soft tissue on in vivo accuracy of bone mineral measurements in the spine, hip, and forearm: a human cadaver study.

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·1995
    Same author

    [The osteoporosis profile].

    Ugeskrift for laeger·1995

    Area of Science:

    • Endocrinology
    • Psychiatry
    • Bone Metabolism

    Background:

    • Manic depressive illness (bipolar disorder) requires long-term pharmacological treatment.
    • Lithium is a common mood stabilizer for bipolar disorder.
    • Potential side effects of lithium on mineral metabolism are not fully understood.

    Purpose of the Study:

    • To investigate the effects of lithium treatment on bone mineral content and serum levels of parathyroid hormone (iPTH), calcium, and magnesium.
    • To explore the potential link between lithium therapy and alterations in calcium homeostasis.

    Main Methods:

    • Measurement of bone mineral content.
    • Assay of serum levels of immunoreactive parathyroid hormone (iPTH).
    • Quantification of protein-corrected calcium and magnesium in 13 manic depressive patients before and during lithium treatment.

    Related Experiment Videos

    Main Results:

    • Bone mineral content decreased during lithium therapy.
    • Serum levels of iPTH, calcium, and magnesium increased with lithium treatment.
    • Initially normal parameters showed significant changes during treatment.

    Conclusions:

    • Lithium treatment appears to negatively impact bone mineral density.
    • The observed increases in iPTH, calcium, and magnesium suggest lithium may induce a state of mild primary hyperparathyroidism.
    • Early monitoring of mineral metabolism is recommended for patients on long-term lithium therapy.