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Related Experiment Videos

LSD 'flashback' as a cause of diagnostic error

J A Smith, G Walters, D Johnston

    Postgraduate Medical Journal
    |June 1, 1980
    PubMed
    Summary

    A young man experienced acute psychosis mimicking drug use due to severe pyloric stenosis. This physical condition caused severe biochemical abnormalities, leading to a prolonged psychotic state mistaken for an LSD flashback.

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    Area of Science:

    • Gastroenterology
    • Psychiatry
    • Biochemistry

    Background:

    • Pyloric stenosis, a physical obstruction of the gastric outlet, can present with atypical symptoms.
    • Acute psychosis is typically associated with psychiatric disorders or substance abuse.

    Observation:

    • A physically normal but emaciated young man presented with acute psychosis.
    • His behavior was severe enough to mask an underlying medical condition.
    • Biochemical abnormalities were discovered incidentally through urea and electrolyte measurements.

    Findings:

    • The patient's psychosis was caused by severe pyloric stenosis.
    • Gross biochemical abnormalities were identified as the underlying pathology.
    • The abnormal mental state persisted for over a week.

    Implications:

    • This case highlights the importance of considering physical pathologies in unexplained acute psychosis.
    • Severe pyloric stenosis can manifest with psychiatric symptoms, challenging initial diagnosis.
    • Thorough biochemical assessment is crucial for identifying underlying causes of prolonged psychosis.

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