Synthesis and anti-inflammatory activity of certain new N,N'-oxamides

Some new amides of substituted oxamic acid which embody different moieties of the anti-inflammatory drugs were prepared through two routes of synthesis. The physico-chemical properties as well as the anti-inflammatory activity of these compounds were determined. Preliminary pharmacological testing revealed the superiority of most of the screened compounds as anti-inflammatory agents with relatively low toxicity as compared with acetylsalicylic acid. Correlation between structure and biological activity was suggested.