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Related Experiment Videos

In vitro antidiabetics-antacid interactions

V F Naggar, S A Khalil

    Die Pharmazie
    |January 1, 1980
    PubMed
    Summary

    Antacids and adsorbents show varied binding with oral antidiabetic drugs. Magnesium trisilicate and calcium carbonate best adsorb metformin hydrochloride, while charcoal has broad adsorption properties.

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    Area of Science:

    • Pharmacology
    • Drug Interactions
    • Physical Chemistry

    Background:

    • Oral antidiabetic drugs are widely prescribed for managing diabetes mellitus.
    • Concomitant use of antacids or adsorbents is common for gastrointestinal issues.
    • Potential interactions between antidiabetics and antacids can affect drug bioavailability.

    Purpose of the Study:

    • To investigate the adsorption of seven oral antidiabetic drugs onto various antacids and adsorbents.
    • To evaluate the impact of these interactions on drug dissolution rates.
    • To discuss potential implications for the bioavailability of antidiabetic medications.

    Main Methods:

    • In vitro study at 37°C.
    • Tested adsorption of metformin hydrochloride, glibenclamide, acetohexamide, tolbutamide, carbutamide, tolazamide, and glymidine.
    • Utilized adsorbents: magnesium trisilicate, aluminum hydroxide, calcium carbonate, magnesium oxide, bismuth oxycarbonate, talc, kaolin, and charcoal.

    Main Results:

    • No single adsorbent showed superior properties for all drugs, except charcoal.
    • Magnesium trisilicate and calcium carbonate were most effective for metformin hydrochloride.
    • Acetohexamide and glibenclamide showed significant adsorption on most antacids; tolbutamide adsorbed to talc; carbutamide showed slight adsorption.
    • Magnesium trisilicate demonstrated higher adsorption for tolazamide and glymidine.
    • Dissolution rate of acetohexamide increased significantly in magnesium oxide and magnesium trisilicate suspensions.
    • Metformin hydrochloride dissolution rate was unaffected by magnesium trisilicate.

    Conclusions:

    • Significant variations in drug-antacid adsorption exist among different oral antidiabetics.
    • Specific antacids show preferential adsorption for certain antidiabetic agents.
    • Observed effects on dissolution rates suggest potential alterations in bioavailability.
    • Further in vivo studies are necessary to confirm clinical significance of these drug-antacid interactions.

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