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Recurrence of intracranial meningiomas, with special reference to radiotherapy
Abstract:
Three hundred thirty-six cases of meningioma were analyzed retrospectively with regard to the recurrence rate and the effect of radiotherapy on recurrent meningiomas. There was recurrence in 14 out of 173 cases (8.1%) after apparently complete removal and in 26 out of 90 cases (28.9%) after obviously incomplete removal. Radiotherapy was given in 7 cases after repeat complete removal of recurrent tumors. It was concluded that irradiation in recurrent menigiomas is of little value, although it might be beneficial occasionally. One of the most important limiting factors in application of radiation therapy to recurrent meningiomas appears to be vulnerability to radiation of the surroundng brain, which has been damaged already.
Insights
Recurrent meningiomas are more common after incomplete removal. Radiotherapy offers limited benefit for recurrent meningiomas due to surrounding brain vulnerability.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Meningiomas are primary tumors of the brain's coverings.
- Recurrence rates vary based on surgical completeness.
- The role of radiotherapy in recurrent meningiomas requires further clarification.
Purpose of the Study:
- To analyze the recurrence rates of meningiomas.
- To evaluate the efficacy of radiotherapy on recurrent meningiomas.
Main Methods:
- Retrospective analysis of 336 meningioma cases.
- Comparison of recurrence rates after complete versus incomplete tumor removal.
- Assessment of radiotherapy outcomes in recurrent cases.
Main Results:
- Recurrence observed in 8.1% of cases with apparently complete removal.
- Recurrence observed in 28.9% of cases with obviously incomplete removal.
- Radiotherapy showed limited benefit in 7 treated recurrent cases.
Conclusions:
- Incomplete tumor removal significantly increases meningioma recurrence.
- Radiotherapy has minimal value for recurrent meningiomas.
- Radiation-induced damage to surrounding brain tissue limits radiotherapy efficacy.