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Titanium retention in mice

R G Thomas, R F Archuleta

    Toxicology Letters
    |July 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Titanium-44 (44Ti) chloride showed minimal body fluid translocation and interorgan exchange in mice following intraperitoneal or intravenous injection. Its insolubility suggests low bioavailability and acceptable occupational exposure limits.

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    Area of Science:

    • Biomedical science
    • Toxicology
    • Radiochemistry

    Background:

    • Titanium's biological interactions are crucial for understanding its safety.
    • Investigating the behavior of radioisotopes like Titanium-44 (44Ti) is important for both medical and environmental assessments.

    Purpose of the Study:

    • To determine the biodistribution and retention of Titanium-44 (44Ti) following different administration routes in mice.
    • To assess the potential for interorgan exchange and absorption of 44Ti.
    • To provide data relevant to establishing occupational exposure limits for titanium.

    Main Methods:

    • Intraperitoneal (i.p.) and intravenous (i.v.) injection of 44Ti chloride solution into mice.
    • Monitoring of 44Ti translocation in body fluids and interorgan distribution up to 16 days post-injection.

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  • Assessment of gastrointestinal (g.i.) absorption after oral administration via stomach tube.
  • Calculation of whole-body biological retention half-lives.

    • Main Results:

    • No detectable translocation of 44Ti in body fluids was observed after i.p. or i.v. injection.
    • No significant interorgan exchange of 44Ti was evident up to 16 days.
    • Long whole-body biological retention half-lives (mean of 642 days) indicated 44Ti insolubility.
    • Negligible absorption of 44Ti from the gastrointestinal tract was found.

    Conclusions:

    • Titanium-44 (44Ti) exhibits very low bioavailability and limited systemic distribution following parenteral administration.
    • The insolubility of 44Ti in biological fluids supports its negligible absorption via the gastrointestinal route.
    • Study findings support the current threshold limit value (TLV) for titanium in air, considering it acceptable based on low systemic uptake.