[Reproduction of cells of the osteogenic layer of periosteum]

The H3-thymidine autoradiography method was used to prove that the population of osteoblasts in the periosteum of growing bone is replenished due to the reproduction and differentiation of perivascular cells and preosteoblasts. The differentiation of these cells into osteoblasts is accompanied by reduction of their proliferative activity due to an increase in the duration of generation time and progressive getting out of cells from the mitotic cycle.