[Regional chemotherapy of malignant brain tumors with endolumbar methotrexate injection]

Chemotherapy with endolumbar methotrexate injection was carried out on 52 patients suffering from malignant cerebral tumors. Of the patients, 44 had previously undergone an operation with subtotal removal of the neoplasm. The dosage and method for administering the methotrexate injection, and the duration of treatment have been determined. Chemotherapy with methotrexate results in a decrease in the size of the neoplasm which can be recorded by means of instrumental methods of examination. The pathomorphological analysis indicates a distinctly destructive effect of the preparation on malignant cerebral tumors.